A simple, sensitive, precise and stability indicating high performance thin layer chromatographic method of analysis of lacidipine in bulk as well as formulation was developed and validated. The method employed TLC aluminium plates precoated with silica gel 60F-254 as the stationary phase using mobile phase toluene: ethylacetate: glacial acetic acid (6.5:2.5:1 v/v/v). It gives compact spots for lacidipine (Rf value 0.43). The drug was subjected to stress degradation conditions like acid, alkaline, oxidative, photo and thermal degradation. Densitometric analysis of lacidipine was carried out in the absorbance mode at 281 nm. The method was validated for specificity, linearity, precision, accuracy, robustness and solution stability. Method was found to be linear with correlation coefficient 0.998 and also found to be robust as % RSD values are less than 2%. Stress degradation study shows that lacidipine undergoes degradation in acid, base and oxidation (13.41%, 11.29% and 8.49% respectively).
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